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SCI期刊文章寫作常用句型(已編輯好)(合集5篇)

時間:2019-05-13 18:39:35下載本文作者:會員上傳
簡介:寫寫幫文庫小編為你整理了多篇相關的《SCI期刊文章寫作常用句型(已編輯好)》,但愿對你工作學習有幫助,當然你在寫寫幫文庫還可以找到更多《SCI期刊文章寫作常用句型(已編輯好)》。

第一篇:SCI期刊文章寫作常用句型(已編輯好)

SCI文章寫作常用句型

(1).had marked influence on

Eg: The Latin and Arabic alphabets have had marked influence on developments in written African literature.(2).Results shown below indicate that

Eg: Furthermore, the results shown below indicate that a positive AEEI may increase the economic growth rate, further increasing energy use.(3).The Key to…..Lies in…

Eg: The key to becoming[名詞或動名詞] a leader lies in character people follow only those who they respect,trust and admire.(4).play pivotal roles in

Eg: Interferons and cytokines play pivotal roles in achieving this.(5).shows clear evidence that

Eg: Figure 4b shows clear evidence that the I-V curve of this nanowire was ohmic at room temperature.(6).The fact that ……is due to….Eg: The fact Franklin was not injured was apparently due to the shed's protection.(7).Sth prove that

Eg: the data prove that the wires were made largely, if not exclusively, ofpalladium.(8).It remains to be determined whether…will be suitable for…

Eg: It remains to be determined whether our approach will be suitable for other metals.(9).sth behaved as…

Eg: After cutting the wire, the sample behaved as an insulator[絕緣體]。

(10).There are examples in the scientific literature of… being used to…Eg: There are examples in the scientific literature of an applied electric field being used to fabricate nanowires between electrodes.(11).the method outlined here could be used to…

Eg:In principle the method outlined here could be used to self-assemble single nanowires at specified locations between electrodes or devices.(12).gave no obvious change in

Eg: Soaking an array for 10 min in a reducing aqueous environment gave no obvious change in electrical resistance.(13)...be determined to be…

The d-spacing of adjacent lattice planes is determined to be 0.2308 nm.經測定相鄰晶面的間距為 0.2308 納米。

(14)表明研究目的A study + aim at/be aimed at/be designed to

A study + concern/deal with/examine/focus on/investigate/look at/compare…

A study + conclude/demonstrate/find/indicate/report/reveal/say/show /suggest/warns…

A study + highlight/identify…

carry out/conduct/undertake/make/do + an extensive feasibility studya(n)initial/pilot/preliminary + study------time

a(n)earlier/previous + study------time

a(n)new/present/recent + study------time

a(n)scientific/sociological/historical + study------nature

Irony is chiefly a problem of pragmatics rather than lexis.The

difficulty is the mismatch between the apparent meaning and thewriter's underlying intention.(正話反說/反話正說)

e.g.To paraphrase 18th-century statesman Edmund Burke, “all that isneeded for the triumph of a misguided cause is that good people donothing.”… …If good people do nothing, there is a real possibility that anuninformed citizenry will extinguish the precious embers of medicalprogress.(15)A possible explanation is that…一種可能的解釋是…

Eg: A possible explanation of why the habit occurs is that the modelsmay omit electrical effects.(16)Note that there is a key difference between...(17)Given our results, this suggests the presence in the U.S.economy of conditions that favor the Khazzoom-Brookes postulate.(18)The Khazzoom-Brookes postulate says that increases in energy efficiency can lead to increased, not decreased, energy consumption.(19)These results, while by no means proving the Khazzoom-Brookes

postulate.(20)There is an important corollary to this particular result that a high elasticity of substitution causes energy efficiency gains to boost energy consumption.On the surface, this would say that higher elasticity increases the problem of global warming.However, a higher elasticity also means that the cost of restricting energy consumption is less than it is with a lower elasticity.(21)In particular, note that the effect of pure energy efficiency gains on consumption depends substantially on the assumption used for the energy elasticity of substitution.(22)To further underline this possible uniqueness, it is worthwhile reminding ourselves that...(23)Under the deal, which was mainly aimed at doing sth…

Aiming at this situation , this paper puts forward the idea…

(24)These observations led us to hypothesize that...(25)The Study was designed to identify...(26)An increased risk of EPPD was found among infantswithelevated concentrations of A and those with elevated concentrations of B or C.(27)On one level, this is evidence that inflammation does not contribute substantially to the occurrence of PD.Our findings raise the possibility that inflammation protects.We are reluctant to accept this view just yet.(28)Our findings are best interpreted in light of the current

understanding of the biology of inflammation.(29)For example, when the expression of A is increased, so, too, is the expression of other markers of inflammation.Consequently, what we see is a very limited snapshot of what has preceded and/or accompanied the development of lung dysfunction.(30)In essence, a self-reinforcing loop is generated that promotes sustained inflammation, thereby increasing the risk of inflammation-induced damage.(31)We do not know to what extent protein concentrations in the blood are of pulmonary origin.It is possible that under certain circumstances proteins produced by cells in the lung remain in the lung compartment, whereas under other circumstances(e.g.intense or prolonged pulmonary inflammation), they enter the circulation.(32)The precision and accuracy with which devices can be assembled in this way is significant.(33)The past decade has witnessed rapid growth in research on nanostructures, which has been driven by their unique electrochemical and electronic properties,as well as by the processing advantages of polymers relative to inorganic electronic materials.

第二篇:SCI文章寫作經典例句(范文)

個人認為,對于大多數寫sci的作者,包括小弟在內,poor english是最常被編輯們提出來的問題。找潤色公司等等,也需要人民幣。因此,小弟將一些經典的英語中的句子,包括描述趨勢,描述大小等的句子,放入。。也希望其他高手們也一起來完善這項工作。這樣,以后,我們也可以寫出比較地道的句子,而不被別人詬病。以后,每天10句,日積月累下來,大家都可以用。

1、表示與某某研究不同:Our results are seemingly at variance with a previous study that。。(例如:evaluated FDG uptake in irradiated bone marrow and other tissues in rodents)

2、表示與某某研究相同:。。are(is)in agreement with the results of previous studies.原句:The changes in the percentages of neutrophils in this study are in agreement with the results of previous studies.3、表示某種變化可能是兩種機制共同作用。當某種機制占上風時,會導致。。變化,反之,當另一種機制占優勢的時候,會。。。要描述這種東西很難。特別是在討論的概括。因此,用這個句子:

...may be explained by the trade-off between...and.....原句:The increased FDG uptake observed on day 1 in the irradiated marrow may be explained by the trade-off

between the infiltration of neutrophils and the relatively decreased cellularity.4、稱贊自己的結果如何如何牛,而且還有更深層次的用途:

Our results in...model suggest potential uses for...in the.......In a broader sense, they also make a case for using...to...other......原句:Our results in the EAE model suggest potential uses for [18F]FDG PET/CT in the diagnosis and monitoring of other disorders characterized by hyperactive immunity.In a broader sense, they also make a case for using PET to measure other metabolic pathways as functional readouts of immune activation.5、表明可以用于預測。。(例如預后,治療反應等)

Our results demonstrate(or reveal)that....can.....and possibly allow early prognostic assessment of....原句:Our clinical results demonstrate that FDG-PET imaging can advance noninvasive diagnostic mapping and monitoring of intestinal GVHD and possibly allow early prognostic assessment of GVHD responsiveness to therapy.6、用于討論開場白。

The initial question that motivated our study was to determine whether。would prove useful in

原句:The initial question that motivated our study was to determine whether molecular imaging with [F]-FDG-PET/CT would prove useful in diagnosing radiation-induced haematopoietic injury.今天先更新到這里。。我個人認為這絕對不是抄襲,僅僅只是用一下人家的結構而已。也有人說這樣會導致全文的行文等看起來很怪異。但是我個人認為對于那些苦哈哈戰友,這種套寫不失為一種實用的方法。畢竟很多低分SCI人家的要求僅僅只是能看懂。。。18

第三篇:分享SCI文章寫作的經驗

很高興,今天我的第一篇SCI文章接受了。

這文章經過了多次修改,眼睜睜的從一個不知道什么事發文章的新手逐漸成長起來。

其中經歷了種種坎坷,在此把我的經驗分享,希望對正在為文章而奮斗的戰友有些作用。

文章寫作及投遞投遞的注意事項

Lin123heng原創,轉載請注明出處

謹以此文感謝我的敬愛的導師,師兄師姐

1.實驗過程

(1)在決定課題時就要有整體的規劃。文章分幾個故事,每個故事講什么。

(2)實驗可先做主線,在實驗的空余時間做支線的數據。

(3)基本上每個故事的實驗數據制成一副圖。保證數據的質量。

2.文章寫作。

(1)在做實驗的空余時間就可以進行文章的準備工作。

工具軟件:endonote。學會使用其進行文獻的編排,整理,插入,排版,解除鏈接。構思introduction的內容。邊寫邊插參考文獻。

(2)實驗基本成形時即可以選擇要投遞的雜志。注意研究的方向,研究方法,數據的質量和雜志中的文章相近或略高。

(3)編排圖片、結果部分。

此時要注意雜志的要求。到雜志的官方網站上查閱guide to authors.最好把它打印下來,好好看兩天,讀懂每句話。這是決定今后文章質量的重要標準。讀明白了就可已進行下面的工作了。1>圖片處理

單張圖片:

注意dpi,圖片尺寸。看各雜志的要求。

Western:注意條帶上下留下足夠的間隙,挑選優質的圖片,最好沒有非特異性條帶。排列整齊,最好一張圖片的結果是由一張膜得出來的。

免疫熒光:可以選取視野中比較好的部分,每張圖中的細胞密度相近。包含fitc,hoechest,merge三部分。各部分視野內容一定要一致。如果對標尺沒有信心的話就不要學人家打標尺,會鬧笑話的。

線圖:使用專業的制圖軟件。千萬不要使用EXCEL!推薦使用origin.注意線圖的dpi.排圖:

注意雜志要求的尺寸,dpi。

同一類型的圖片注意使其背景色調一致(photoshop)

圖標要清晰,文字的字體,大小,要符合文章的要求。

每張圖片最好講一個故事,圖片數量符合雜志要求。把缺少的圖片空余出來,獲得后補入。

2>results部分。數據齊全時就可以寫results部分了。注意句式,語法,專業術語的描繪。最好每句話都到google上查一下,會不會出現:“您是不是要找。。”自己沒有很好的語言天賦也沒關系,找類似的文章,學習被人的語言技巧。不要照抄!

3>discussion部分。Results 部分寫完后就寫discussion部分,這部分最難。多和老師同學談一談,會有一定的幫助!

4>Material 部分。注意要和其他文章描述相一致。實在不行就用參考文獻!如果有原創的方法最好在discussion有合理的解釋。不要說你用的是國產試劑盒,容易被懷疑質量問題。注意公

司產地的格式。

5>最后寫abstract部分。Abstract 是對文章內容的高度凝練,要有字字值千金的態度。寫完之后,你的所有內容就是第一份manuscript 了。

6>修改。下面是痛苦的修改。

首先是自己修改,注意不要拿半成品給被人看,會嚴重打擊自信心!

檢查的主要內容:

1錯別字:把word的糾錯系統打開,所有畫橫線的部分都要檢查!專業詞匯就去google確認,確認后在文章中右鍵,全部忽略,橫線就消失了。改到沒有橫線為止!語法,注意時態一致,單復數。多看看語法書。誰說高中的語法是廢物!句式,學習科技論文的句式。邏輯,要嚴謹。This is the first report… must.一定要小心使用。排版,注意行間距,注意縮進,文章各部分的字體和要投的雜志一致。主要有兩個字體: Arial, times new roman.這兩種字體是有區別的。主要在a g i a g i有不同(前面是Arial,后面是times new roman)。仔細觀察各部分用什么字體。

感覺不錯了,還是忍一下。第二天打印出來,找個沒人的地方放聲朗讀!很管用!總會發現問題的。等讀順了,就給周圍的人看看。請其他人幫忙修改。記住不要再別人修改的結果上修改,每次只在自己的版本上修改。修完之后另存為,文件名為(名稱+修改時間)的格式。每次只在最新版上修改。

6投遞前把reference解鏈接。

這是前面一段時間的親身的體驗,現在文章已被接受。把經驗分享,希望對各位戰友有所幫助。

最后祝愿大家實驗順利,文章accept!

Lin123heng

School of Stomatology Wuhan University

第四篇:醫學SCI期刊接受的文章類型及寫作技巧(模版)

醫學SCI期刊接受的文章類型及寫作技巧

醫學SCI期刊接受的文章都有一定的要求,達到要求就被收錄,反之則拒之門外。了解醫學SCI期刊接受的文章類型的寫作技巧尤為重要。

一、Original article/paper論著

論著最為常見,基礎研究和臨床研究往往以論著形式發表。中英文論著的論文格式和寫作要求絕大多數人已十分熟悉。需要強調的是另兩種不太關注的論著形式,即生活質量研究(Quality of Life research)和醫學假說(Medical hypothesis)。就像宣傳介入不能只強調“社會主義好”,而應當進一步向臨床科室解釋“社會主義為什么好”一樣。生活質量研究以客觀數據反映患者生活質量改變,能有力回答介入治療“為什么好”,而不是主觀地認為“介入治療后患者生活質量顯著提高”!

醫學假說常常被誤解成“不務正業”,但恩格斯說過“只要自然科學在思維著,它的發展形式就是假說”,大陸漂移假說和本人系天天論文網就職11年的資深論文編輯;工作中與各大醫學期刊雜志社進行學術交流過程中建立了穩定的編輯朋友圈,系多家醫學雜志社的特約編輯,常年為醫學期刊雜志供稿,負責天天論文網醫學論文·分檢·編校·推送·指導等工作!工作企鵝1:1550116010工作企鵝2:766085044愛因斯坦的《相對論》都是著名的科學假說。在醫學實踐中,遇到臨床問題并提出獨到的設想,往往因臨床繁忙而忽視了查閱文獻進一步形成醫學假說,而將其發表者更少。醫學假說寫作,也是個學習過程和課題立項過程,我本人讀博做實驗期間,成功發表兩個假說,并通過具體的實驗得到證實。

二、Case report個案報道

個案報道對臨床工作者是種很好的論文形式。臨床中遇到罕見、少見病例或者典型病例,可以查詢中外文文獻了解有無類似病例報道,有些在國內常見的病例,國外可能很少見,這些都可以寫成case report發表。寫作過程通過查詢文獻能更加全面而深入了解該疾病,既提高對疾病的認識,又提升了外文寫作水平,可謂臨床與科研雙贏!能成功發表的個案,一般要求首例報道(時效性),少見、罕見(獨特性),且能夠證明某個假說或理論(科研價值)。

三、Case series病例系列研究

系列病例報導和個案報道類似,一般會列舉類似的臨床病例。例數不定,少者4-10例,多者數百例。

四、Review article綜述

國外綜述與國內博士/碩士論文中的綜述不同,期刊一般采用邀稿形式,由編輯委員會邀請學術領頭人(權威專家)撰寫,也可能倡導某種理論或學說。一般約5000字,參考文獻有幾十到數百條。某些雜志可以發表簡短的綜述,約1000字左右。部分雜志也接受非受邀的綜述投稿,具體可查詢雜志的投稿說明(Instruction for Authors)。

五、Letter to editor、correspondence信

致編輯函/信是讀者針對某篇感興趣的文章寫的讀后感,或延續要告訴期刊內容。字數限制約300-500字,也有雜志要求不超過150字,一般無具體格式要求。雜志接受針對最新發表論文寫的letter(時效性),超過規定的時間不再接收。讀者若具備相應研究基礎,能提出獨到觀點,一般容易被雜志接收,甚至是一些頂級醫學雜志。近期,我成功發表數篇letter,對兔腹主動脈瘤模型形成機制的“經典理論”提出質疑,得到國外專家某種程度的認可。

六、Comment、invitedcommentary、editorial評論

對最新發表(時效性)的某篇論文進行評論,一般是雜志邀請相關領域專家進行受邀評論,被評論的文章往往具有重大臨床或科研意義。我科發明的“子彈頭”支架治療支氣管胸膜瘺,以及“蘑菇”支架治療胃吻合口瘺的新技術,均發表在權威雜志《Ann Thorac Surg》上。雜志分別邀請香港中文大學AnthonyP.C.Yim教授和Austin Health胸外科專家Charles Peter Clarke進行評論,兩位國外專家均充分肯定了該新技術在解決臨床問題所做出的突出貢獻,給予高度評價。

七、Short Communication、RapidCommunication短訊

短訊較為少見,其結構類似orginalarticle,字數約1500-2500。

八、非傳統雜志

當今多媒體、自媒體時代,論文除了上述紙質媒介雜志常見形式外,也出現僅電子版論文、視頻論文和eletter等多種形式。以往的SCIE論文,是指SCI論文的電子擴展版(SCI Expanded),隨著電子版論文比例增多,現兩者已無本質區別,故多數院校不再區別SCIE和SCI論文。比如年發行量超過20000篇論文的綜合雜志PLoS one,僅發行電子版論文,還沒有紙質版。

JoVE-JOURNAL OFVISUALIZED EXPERIMENTS,接收科研視頻,即將經典術式或實驗建模等過程錄制成視頻發表,以便讀者更為直觀地了解并獲取信息。eletter即comment letterto editor,僅為電子版而沒有紙質版。比如影響因子高達5.533的Arteriosclerosis Thrombosis and Vascular Biology(ATVB)雜志,接收eletter,且發表迅速。前不久,我本人成功發表一篇eletter于ATVB上,并得到原文作者快速回復,提出諸多建設性意見。

第五篇:本人總結關于肺癌的SCI寫作的常用句型

本人總結關于肺癌的SCI寫作的常用句型。

1. Small-cell lung cancer(SCLC)is distinct from the more common non–small-cell lung cancer by its rapid doubling time, high growth fraction, early development of widespread metastases, and dramatic initial response to chemotherapy and radiation

2. However, despite high initial responses to therapy, most patients die from recurrent disease

3. Although squamous cell carcinoma(SCC)and SCLC were the most frequent histologic subtypes of lung cancer in the initial period of the smoking-related cancer epidemic, more recent studies have consistently reported the predominance of adenocarcinoma, which is now recognized as the most common histologic type of lung cancer

4. The American Cancer Society estimated that SCLC represented 25% of the 170,000 new cases of lung cancer in the United States in 1993.Recent studies however have shown a decrease in the total number of lung cancer cases, particularly in men with SCLC and SCCWe analyzed the Surveillance, Epidemiologic, and End Results(SEER)program of the National Cancer Institute(Bethesda, MD)to determine the changes in incidence, proportion of SCLC among new cases of lung cancer, and survival rates for patients with SCLC during the period from 1973 to 2002

5. As of 2002, SCLC comprised only 12.95% of all lung cancers

6. outlines the characteristics of patients with small-cell lung cancer as identified in the SEER data set from 1973-2002.7. It increased modestly between 1982 and 1989 at an annual percentage change rate of 1.2% that was not statistically significant.8. This downward trend is statistically significant(P <.0001), suggesting that this decrease is a real trend rather than random fluctuation.9. Our analysis of the SEER database indicates that the incidence of SCLC has been steadily decreasing in the United States over the last several years

10. The decrease in the incidence of SCLC may be explained by the decreased percentage of smokers and by the change in cigarette composition.11. Several studies of patients with SCLC have shown improved survival rates in women compared with men.In a study comparing the survival of women and men treated from 1973 to 1986 at the National Cancer Institute, both the rates of median survival(13 months v 10 months)and of survival beyond 2.5 years(15% v 6%)favored women.23

12. Similar findings were reported in a large retrospective analysis of five studies conducted by the Cancer and Leukemia Study Group

B(CALG between 1972 and 1986, in which women had improved response rates and long-term survival.13. A retrospective review by the Southwest Oncology Group(SWOG)reported that the improved survival rates in women was restricted to patients with limited-stage disease

14. Improved outcomes for women have been previously suggested by large retrospective studies but the overall improvement in survival for both men and women over the last 30 years is very modest

15. SCLC is strongly associated with cigarette smoking and consequently it is a highly preventable disease

16. Prophylactic cranial irradiation(PCI)has been shown to provide survival benefit in patients with limited disease small-cell lung cancer(LD-SCLC)who have achieved complete response

17. We developed a decision-analytic model to compare quality-adjusted life expectancy(QALE)in a cohort of SCLC patients who do or do not receive PCI by varying survival rates and the frequency and severity of PCI-related NT.Sensitivity analyses were applied to examine the robustness of the optimal decision.18. The current data suggest PCI offers better QALE than no PCI in LD-SCLC patients who have achieved complete response

19. Approximately 14% to 24% of SCLC patients have demonstrable CNS metastases at initial presentation, usually in combination with other extrathoracic sites

20. Even after initial response to chemotherapy, the incidence of clinically detectable brain metastases increased with increased length of survival and reaches 50% at 2 years.21. Moreover, treatment of brain metastases is unsatisfactory—only about half of patients achieve a useful palliation after whole-brain irradiation, and median survival is less than 3 months after metastasis to the brain

22. In considering the poor outcome of patients who developed brain metastases, Hansen7 proposed prophylactic brain irradiation, later

renamed prophylactic cranial irradiation(PCI), for all patients with SCLC.23. During the last three decades, there has been much debate on whether and how PCI should be used in the management of SCLC

24. The point of contention centers on the determination of the risks of short-term and long-term toxicity and benefits of reduction in brain metastasis and prolonging overall survival by PCI

25. Because of the intense research8-31 and two recent meta-analyses, a general consensus has been reached in the following areas: PCI is recommended for patients with limited disease(LD)SCLC who have achieved complete response(CR);the commonly accepted dose of PCI ranges from 24 to 36 Gy, with once-daily or twice-daily fractions equal to 2 to 3 Gy/d;

26. PCI and concomitant chemotherapy can increase toxicity and should be avoided;PCI significantly reduces the risk of brain metastasis by approximately 50%(hazard ratio, 0.46and 0.48);PCI prolongs survival(hazard ratio for mortality, 0.84 and 0.82);and acute radiation-induced toxicities are typically mild and resolved within a few months.27. Despite the above-described advancements, only limited data on long-term PCI toxicities are available

28. To date, there are no reliable data to estimate the frequency and severity of the long-term toxicities induced by PCI

29. PCI is now routinely recommended for those patients who achieved CR to chemotherapy

30. Moreover, as more effective chemotherapy and combined chemoradiation improves the overall outcome and long-term survival of SCLC patients, the potential risk of chronic NT will be greater and the quality of life(QOL)becomes a more important consideration among the long-term survivors.31. Given that PCI has become a standard treatment for LD-SCLC patients who have achieved CR, it is no longer ethical to conduct randomized controlled trials including an arm with no PCI

32. There is general agreement that patients with small-cell lung cancer(SCLC)and good performance status should be offered chemotherapy and when indicated, radiotherapy, aimed at prolonging survival and achieving a proportion of cures.33. The use of carboplatin avoids the nephrotoxicity, neurotoxicity, and ototoxicity associated with cisplatin, and carboplatin can be substituted for cisplatin without survival detriment or the fluid loading needed with cisplatin, which can be problematic in lung cancer patients

34. Phase II studies of ICE and ICE-V, followed by thoracic and prophylactic cranial radiotherapy when clinically indicated, in patients with good performance status and limited-stage(LS)or extensive-stage(ES)SCLC, reported complete response rates in excess of 50% and 2-year survival rates ranging from 24% to 33% for LS and 14% to 23% for ES

35. However, because these instruments had not been compared previously in a randomized fashion, this trial represented an opportunity to compare them in terms of compliance and ability to detect differences between regimens to guide the selection of QL instruments in future trials.36. to compare these two chemotherapy policies in terms of adverse effects of treatment and QL

37. This randomized trial has shown that a regimen of ICE-V administered every 4 weeks significantly prolongs survival compared with standard, mainly nonplatinum-based chemotherapy administered every 3 weeks in the treatment of patients with SCLC and good performance status

38. Perhaps counterintuitively

39. The benefit seen in the current trial with a platinum-based regimen is echoed by two retrospective reviews, a meta-analysis based on published data, and one more recent trial

40. A review of SCLC patients treated at the US National Cancer Institute suggested a modest survival benefit for PE in LS patients

41. Treatment for patients with SCLC and a good PS might be improved by adding one or more drugs to platinum/etoposide, dose intensification, the use of concurrent chemoradiotherapy, or the use of new drugs

42.There are a number of ways of increasing the total dose and the dose-intensity of chemotherapy: increasing the number of cycles, increasing the dose per cycle, decreasing the interval between cycles, or combinations of these.A meta-analysis of the published literature28 suggested that all of these strategies are relevant for improving survival, although not all individual trials show this pattern

43.Although there are proven survival benefits in adding radiotherapy to chemotherapy for LS SCLC patients,30,31 the optimum timing of radiotherapy is unclear

44.A recent meta-analysis of fully published trials32 indicated a benefit for early thoracic radiotherapy, particularly in conjunction with PE chemotherapy and with hyperfractionated radiotherapy

45.A Japanese trial35 comparing concurrent chemoradiotherapy(PE with 45 Gy administered in twice-daily fractions starting with cycle 1 every 4 weeks)and sequential treatment 4(cycles of PE administered every 3 weeks with the same radiotherapy administered after cycle 4)showed a much improved median survival with concurrent treatment(27.2 v 19.7 months)although with only 231 patients, this did not translate into a statistically significant difference

46.The emergence of newer cytotoxic drugs may also offer opportunities to improve the outlook of patients with SCLC

47.Although all the above strategies are worth pursuing, the future probably lies with biologically targeted agents;SCLC exhibits numerous molecular abnormalities, including neuropeptide, gastrin-releasing peptide, CD117, and vascular endothelial growth factor expression, which may be exploitable

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